Effect of Calcitonin on Meal-Stimulated Gastric Acid Secretion and Serum Gastrin Concentration

Effect of Esophageal Distention on Basal and Stimulated Gastric Acid Secretion in Rats

It is well established that the esophageal distention (ED) leads to gastric relaxation, partly by vago-vagal reflex, but till now, the effect of ED on gastric acid secretion has not been investigated. The aim of this study was to investigate the effect of ED on basal and stimulated gastric acid secretion. Methods: Adult male Wistar rats (200-240 g) were deprived of food but not the water 24 h b...

The effect of bromocriptine on basal and histamine-stimulated gastric acid secretion in anesthetized rats

Introduction: The protective and antisecretory effects of dopamine agonists on the stomach have been already reported, but the effect of bromocriptine (D2 dopamine agonist) on histamine stimulated gastric acid secretion (GAS) needs to be investigated. Methods: For gastric sampling, animals were anesthetized and a polyethylen tube was introduced into the stomach through esophagus. A cannula ...

Effects on Basal and Bombesin-Stimulated Serum Gastrin and Gastric Acid Secretion

Effect of long-term cimetidine on gastric acid secretion, serum gastrin, and gastric emptying.

Gastric acid secretion, gastric emptying, fasting serum gastrin and the serum gastrin response to a meal were measured in duodenal ulcer patients before, and at least five days after completing prolonged treatment with cimetidine (1 or 2 g/day for four or eight weeks followed by 600 mg twice daily for six months). Fasting serum gastrin and the gastrin response were also measured during treatmen...

Effect of simulated intragastric haemorrhage on gastric acid secretion, gastric motility, and serum gastrin.

The majority of upper gastrointestinal bleeds stop spontaneously despite the low pH and proteolytic activity of gastric juice which inhibit coagulation and platelet aggregation. In order to investigate this paradox six healthy male volunteers received intragastric infusions of 160 ml autologous venous blood or 160 ml egg white acting as control in random order on separate days. Basal acid outpu...